Multifactor dimensionality reduction analysis for detecting SNP-SNP, SNP-environment interactions associated with polycystic ovarian syndrome among South Indian women
نویسندگان
چکیده
منابع مشابه
SNP analysis of follistatin gene associated with polycystic ovarian syndrome
Follistatin has been reported as a candidate gene for polycystic ovarian syndrome (PCOS) based on linkage and association studies. In this study, investigation of polymorphisms in the FST gene was done to determine if genetic variation is associated with susceptibility to PCOS. The nucleotide sequence of human follistatin and the protein sequence of human follistatin were retrieved from the NCB...
متن کاملMultiple testing for SNP-SNP interactions.
Most genetic diseases are complex, i.e. associated to combinations of SNPs rather than individual SNPs. In the last few years, this topic has often been addressed in terms of SNP-SNP interaction patterns given as expressions linked by logical operators. Methods for multiple testing in high-dimensional settings can be applied when many SNPs are considered simultaneously. However, another less we...
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BACKGROUND Genetic factors are believed to play an important role in the etiology of polycystic ovarian syndrome (PCOS) which is the most common endocrinological disorder of women in their reproductive age. Androgen metabolism is impaired in PCOS and, thus, CYP19 gene which is involved in this pathway can be a candidate gene. Previous studies have shown a relationship between single nucleotide ...
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In association studies, the combined effects of single nucleotide polymorphism (SNP)-SNP interactions and the problem of imbalanced data between cases and controls are frequently ignored. In the present study, we used an improved multifactor dimensionality reduction (MDR) approach namely MDR-ER to detect the high order SNP‑SNP interaction in an imbalanced breast cancer data set containing seven...
متن کاملSNP Analysis System for Detecting Complex Disease Associated Sites
We developed a system that supports disease association studies to detect genes that may cause complex diseases. The main function of the system is to examine the possibility of each polymorphism being associated with a disease. Another important function is to perform linkage disequilibrium analysis and combine SNPs (Single Nucleotide Polymorphisms) together into LDblocks (Linkage-Disequilibri...
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ژورنال
عنوان ژورنال: International Journal of Molecular Biology: Open Access
سال: 2019
ISSN: 2573-2889
DOI: 10.15406/ijmboa.2019.04.00098